Optisense Technologies


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Optiqua Technologies


 Water related activities of Optisense are concentrated in the subsidiary Optiqua Technologies. 

 

Optiqua Technologies is a provider of innovative tools for both online and sample based water quality monitoring. Optiqua develops and produces innovative optical biosensor technology for the real-time detection of contaminants in water. Optiqua is based in the Netherlands and Singapore, where it has development and production facilities. Optiqua serves water utilities around the globe with our ground-breaking solutions. 

 

Optiqua has the following products. For more details about our products, please visit: www.optiqua.com

 

Optiqua Logo

 Optiqua EventLab™ 

EventLab is based on the awarded and patented Lab-on-Chip sensor technology developed at Optisense. The technology measures refractive index changes of the water matrix induced by a contaminant, without the use of chemicals or other consumables. EventLab sensors respond to the entire spectrum of possible chemical contaminants at ppm level.


 
The sensors are supported by a web-based software, EventLab Online, which provides our customers with a web based user interface, real time alerting and a network wide overview. EventLab Online is optimised for use with large sensor networks. It integrates real time algorithms for data validation and analysis, identify relevant contaminations in real-time in the distribution grid.

 

Optiqua works closely with its launch customers Vitens (the Netherlands) and Public Utility Board (PUB, Singapore). After extensive trials, the Optiqua EventLab system has been rolled out, and both utilities now operate an extensive network of Eventlab sensors.

 

Optiqua MiniLab™


The Optiqua MiniLab is a compact sensing platform designed for label-free biosensing. It utilizes optical interferometry to detect refractive index changes taking place near the surface of an optical chip. The Optiqua MiniLab is delivered as a complete package including a fluidics system, electronics, an optical detection system and software.

The sensor chip is housed in a cartridge which is docked into the MiniLab to allow quick and easy loading and unloading of biosensor chips. The cartridge includes a microfluidic flow cell and the necessary electronic and optical connectors.


The Optiqua MiniLab is fully programmable in terms of pump rates and valve switching. The injection of the sample is done manually. Everything else, including the analysis of the results, is performed in the custom-designed software environment.

 
MiniLab

 Potential Applications

A potential application of the Optiqua MiniLab is a competition (inhibition) assay to determine the concentration of a low molecular weight contaminant in a sample. A derivative of the target analyte is first immobilized on the surface of the MiniLab chip, and the sample to be tested is mixed with an antibody specific to the target analyte. After incubation, the solution is injected into the MiniLab and the resulting binding response is measured. If the analyte concentration is high in the sample, a large proportion of the antibodies will be occupied by the target molecule and unable to bind to the surface of the MiniLab chip. The total time of the injection and analysis of a sample, from start to finish, is less than 10 minutes. The outcome is immediately reported on the computer screen.


Being a refractive- index sensitive method, the biosensing principle used in the MiniLab has similarities with other optical biosensing methods, such as surface plasmon resonance. The same types of applications and methods can be developed for the MiniLab system as well.


Typical tests include either specific pesticides, pharmaaceuticals, chemical compounds or broader chemically related groups. Typical sensitivities are in the low ppb concentration range.


Optiqua has extensive know-how and experience in developing suitable surface chemistries and assay formats for the MiniLab. We would be happy to discuss applications with you!

 

 

Assay2

MiniLab Technology

The Optiqua MiniLab is a fiber optic interferometry sensing system utilizing the Mach–Zehnder interferometer (MZI) concept in a compact sensing platform. It is designed to detect and monitor real-time binding events at the molecular level. Quantitative, semi-quantitative and qualitative information of the analyte concentration can be obtained with MiniLab through appropriate assay development. MiniLab measures binding directly, by either rate-based (i.e., slope of the binding curve), or end-point-based (i.e., step response of the binding curve). The included software lets the user analyze the binding response with high sensitivity, thereby allowing real-time and in-situ monitoring of the chemical/bio-chemical interactions that take place on the chip sensing surface.